Figure 6.

Decreased frequency of mEPSCs in DG granule cells from Sorbs2 KO mice. A, B, Representative traces showing mEPSCs of DG granule cells from WT and Sorbs2 KO mice, respectively. C, D, Summarized data demonstrating the reduction in frequency but not amplitude of mEPSCs in Sorbs2 KO mice (WT: n = 26 of 6 mice, HET: n = 8 of 3 mice; KO: n = 25 of 6 mice). ***p < 0.0001 (one-way ANOVA with Bonferroni's post hoc analysis). E, Representative hippocampal DG slice showing the position of the concentric bipolar stimulating electrode for the stimulation of the LPP. F, Representative traces of evoked EPSCs of DG granule cells from WT and Sorbs2 KO mice upon paired-pulse stimulation (paired stimuli pulses of 50 ms interval) of the LPP. G, The paired-pulse ratio in slices of Sorbs2 KO mice was not different from that of WT mice. p = 0.9978 (two-tailed t test). H, LTP induced by burst high-frequency stimulation (HFS) in slices was comparable between WT and Sorbs2 KO mice. I, Similar level of LTD were induced in slices from WT and Sorbs2 KO mice by 900 pulses stimulation delivered at 1 Hz interval. Error bars indicate SEM.