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. 2016 Feb 13;3(1):ENEURO.0085-15.2016. doi: 10.1523/ENEURO.0085-15.2016

Figure 7.

Figure 7.

Impact of AIS plasticity on neuron excitability. A, Plots of mean changes in rheobase currents (percentage ±SD) observed after elongating or shortening a 30-µm-long AIS by 5, 10, or 15 µm across all possible AIS locations (within 100 µm of the soma) in model neurons having the indicated number of dendrites (AIS Model D; myelinated axon). Uniform sodium and potassium conductance densities were maintained across all AIS lengths (i.e., increasing AIS length proportionally increased total maximum sodium and potassium conductances). B, Plots of the mean absolute values of changes in rheobase (percentage ±SD) observed after translocating a 30-µm-long AIS by 5, 10, or 15 µm across all possible AIS positions within 100 µm of the soma (e.g., 14 possible 5 µm shifts of the 30 µm AIS) in neurons having the indicated number of dendrites (AIS Model C). To facilitate comparisons, data are shown at the same scale as in A, with a close-up of the data inset.