Table 1:
Compartment | Dimensions (length × diameter) |
Segments (n) | Max gNa+/gK+ (pS/µm2) |
Dendrites | 300 µm, tapered from 2.5 to 0.5 µm | 101 | Na+, linear decrease, 100-20; K+, linear decrease, 100-20 |
Somata | 20 × 20 µm | 11 | Na+, 100; K+, 100 |
Proximal axon | 0-100 × 1.5 µm | ∼1/µm | Na+, 100; K+, 100 |
AIS | 5-100 × 1.5 µm | ∼1/µm | Na+, 8000; K+, 2000 |
Myelin segments (20) | 100 × 1 µm | 21 | Passive; CM/10, RM · 10 |
Nodes of Ranvier (20) | 1 × 1.5 µm | 3 | Na+, 2,667; K+, 667 |
Unmyelinated axon | 2000 × 1 µm | 401 | Na+, 300; K+, 60 |
Axon endpoint | 10 × 10 µm | 11 | Passive; CM · 2, RM/2 |
MSN, DGC, Purkinje, L5, and CA3 neurons | Reconstructed morphologies | ∼1/µm | Somata: Na+, 100; K+, 100; Dendrites, passive |
DGC, Dentate granule cell; Epas, reversal potential for passive leak conductance; MSN, medium spiny neuron. General parameters: RM = 15 kΩ · cm2; CM = 1 µF/cm2; Ri = 100 Ω · cm; Epas = −70 mV; time steps, 0.1 or 1 µs; nominal temperature, 37°C.