Table 4.

Meta-analysis for sensitivity of Xpert against reference standard of culture in children by age as well as HIV status, subdivided by smear status

	Specimen type (number of studies, number of children)	Median pooled and predicted sensitivity (pooled 95% credible interval; predicted 95% credibility level)
Smear-positive status
Age 0–4 years	ES and IS (6; 27)12,15,18,22,23,25	94% (79–99; 69–99)
Age 0–4 years	GLA (4; 12)12,14,20,21	82% (51–96; 40–97)
Age 5–15 years	ES and IS (5; 35)12,15,18,22,23,25	96% (85–99; 78–100)
HIV-positive	ES and IS (6; 25)12,15,16,18,22,25	97% (87–100; 82–100)
HIV-negative	ES and IS (7; 41)12,15,16,18,22,23,25	94% (83–99; 75–99)
Smear-negative status
Age 0–4 years	ES and IS (6; 109)12,15,18,22,23,25	44% (30–61; 18–74)
Age 5–15 years	ES and IS (5; 34)12,15,18,22,23,25	66% (44–84; 29–92)
HIV-positive	ES and IS (7; 36)12,15,16,18,22,23,25	60%* (40–77; 26–87)
HIV-negative	ES and IS (7; 125)12,15,16,18,22,23,25	44% (30–59; 18–73)

There were not enough data to assess GLA results in the age group 5–15 years. ES=expectorated sputum. IC=induced sputum. GLA=gastric lavage.

^*Predicted sensitivity is 59% due to rounding.