Table 1. Baseline patient characteristics and treatment regimens.
| Total (N = 345) | Discharged alive (N = 272) | Died in-hospital (N = 73) | p value | |
|---|---|---|---|---|
| Age (years) | 72 (54–82) | 67 (49–79) | 83 (75.5–86) | <0.001 |
| Sex (female) | 134 (38.8%) | 101 (37.1%) | 33 (45.2%) | 0.225 |
| Cavity on X-ray | 144 (41.7%) | 116 (42.6%) | 28 (38.4%) | 0.593 |
| Bilateral infiltration on X-ray | 253 (73.3%) | 189 (69.5%) | 64 (87.7%) | 0.002 |
| Previous history of TB treatment | 38 (11.0%) | 29 (10.7%) | 9 (12.3%) | 0.676 |
| Extra-pulmonary pulmonary TB | 33 (9.6%) | 27 (9.9%) | 6 (8.2%) | 0.824 |
| Diabetes | 88 (25.5%) | 69 (25.4%) | 19 (26.0%) | 0.881 |
| Immunosuppression | 42 (12.2%) | 27 (9.9%) | 15 (20.5%) | 0.025 |
| Chronic cardiac disease | 49 (14.2%) | 30 (11.0%) | 19 (26.0%) | 0.002 |
| Chronic pulmonary disease | 41 (11.9%) | 29 (10.7%) | 12 (16.4%) | 0.220 |
| Chronic liver disease | 40 (11.6%) | 23 (8.5%) | 17 (23.3%) | 0.002 |
| Chronic renal disease | 42 (12.2%) | 28 (10.3%) | 14 (19.2%) | 0.045 |
| Active malignancy | 41 (11.9%) | 26 (9.6%) | 15 (20.5%) | <0.001 |
| Hemoglobin (g/dL) | 11 (9.6–12.7) | 11.4 (10.0–13.1) | 9.9 (8.6–11.2) | <0.001 |
| Aspartate aminotransferase (IU/dL) | 26 (19–44) | 24 (18–38) | 39 (25–76.5) | <0.001 |
| Alanine aminotransferase (IU/dL) | 18 (12–32) | 17.5 (12–30.75) | 21 (14–41.5) | 0.082 |
| Blood urea nitrogen (mg/dL) | 15 (12.0–23.0) | 14 (11.0–19.8) | 23 (16.5–33.0) | <0.001 |
| Creatinine (mg/dL) | 0.65 (0.51–0.90) | 0.65 (0.53–0.88) | 0.67 (0.48–1.12) | 0.501 |
| Treatment regimen | <0.001 | |||
| HRZE | 200 (58.0%) | 182 (66.9%) | 18 (24.7%) | |
| HRE | 114 (33.0%) | 74 (27.2%) | 40 (54.8%) | |
| The other regimens | 31 (9.0%) | 16 (5.9%) | 15 (20.5%) |
Continuous variables were presented as median (interquartile range).
%: proportion to numbers of total patients (N = 345), patients discharged alive (N = 272), or patients died in-hospital (N = 73).
HRZE: isoniazid + rifampicin + pyrazinamide + ethambutol. HRE: isoniazid + rifampicin + ethambutol.
p value: Fisher’s exact test or Mann-Whitney rank sum test was used for binary variables and ontinuous variables, respectively. Treatment regimens were compared using chi-square test.