Table 1.

Summary of the advantages, disadvantages and limitations of each method to obtain cerebral perfusion territories.

Method		References	Territories	Advantages	Disadvantages	Limitations
Separate Labeling RF Coil (CASL)	Full Neck (butterfly)	14, 30, 31	Left and right anterior and middle cerebral circulation (ICA) Posterior circulation (VAs & BA) with post-processing	High SNR 1Lower RF power deposition Unrestricted 3-D coverage due to absence of MT effects	Requires use of additional hardware, not easy to implement in clinical scanner	Can only label circulation of the neck, proximal to COW; distal branches are not accessible
	Single Loop	15, 16, 19	Left and right anterior and middle cerebral circulation (ICA, requires repositioning of RF coil)			Posterior circulation not separable from anterior and middle circulation
Selective Inversion of Spatial Slabs	Single-coil CASL	20	Left and right anterior and middle cerebral circulation (ICA) Posterior circulation (VAs & BA) with post-processing	Does not require additional hardware, easy to implement in clinical scanner	High RF power deposition	Can only label circulation of the neck, proximal to COW; distal branches are not accessible
	PASL techniques	5, 21, 22, 24–28	Left and right anterior and middle cerebral circulation (ICA) Posterior circulation (VAs & BA) Arteries located proximal and distal to the COW	High flexibility of selective labeling of proximal and distal branches of COW	Imprecise delineation of the vascular territories due to imprecise selectivity Artifacts due to overlap of labeling and imaging regions	Tortuosity of vessels may impede clear identification of territories Spatial coverage significantly limited by interference of labeling region with measurement slices
2D Labeling RF pulses		18	In principle, any artery of choice	Highest theoretical flexibility of selective labeling of any artery of choice	Hard to obtain selective 2D pulse without artifacts from side lobes	Moving arterial spins due to blood flow distort the profile of the 2D RF pulse and diminish selectivity

¹When compared to single-coil CASL methods;