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. Author manuscript; available in PMC: 2016 Feb 17.
Published in final edited form as: Cell Rep. 2015 Nov 19;13(9):1965–1976. doi: 10.1016/j.celrep.2015.10.061

Figure 7. Opposing consequences of r1 and r2 5-HTergic neuronal inhibition on forced swim test behavior.

Figure 7

(A–E) In the FST, we assessed floating duration for r1-hM4Di+ mice (green lines) and their controls (black and grey lines) throughout the 6min of FST upon Veh (A) and CNO (B) injections, and for the last 3 min of the test (C) upon Veh (D) and CNO (E). r1-hM4Di+ mice show increased floating behavior as compared to controls when exposed to CNO (B, C), but not when exposed to Veh (A, C). r1-hM4Di+ mice but not controls show increased floating behavior after CNO exposure, when compared to Veh exposure (D, E). n = 11 per genotype.

(F–J) In the FST, we assessed floating duration for r2-hM4Di+ mice (green lines) and their controls (black and grey lines) throughout the 6min of FST upon Veh (F) and CNO (G) injections, and for the last 3 min of the test (H) upon Veh (I) and CNO (J). r2-hM4Di+ mice show decreased floating behavior as compared to controls when exposed to CNO (G, H), but not when exposed to Veh (F, H). r2-hM4Di+ mice but not controls show decreased floating behavior after CNO exposure, when compared to Veh exposure (I, J). n = 18–25 per genotype.

* p < 0.05; ** p < 0.01; *** p < 0.005. FST: forced swim test.