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. 2016 Feb 17;8:20. doi: 10.1186/s13073-016-0272-5

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© Krier et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Mean SNP effect size by a 2-year time period. With larger sample sizes, GWAS were able to detect SNPs with smaller and smaller effect sizes. This brought down the mean effect size for each disease by year (with the exception of PrCa in 2009 which saw a slight bump)