Table 2.

Association between rs75915166 or rs554219 and grade in ductal carcinoma in situ

		Meta-analysis
		OR (95 % CI)	P	Low/intermediate grade, number	High grade, number	Controls, number
rs75915166
Low/intermediate grade vs controls		1.36 (1.17, 1.59)	7.2 × 10-5	1,465		35,521
High grade vs controls		0.92 (0.79, 1.08)	0.31		1,941	32,202
Case-only high vs low/intermediate grade
	Unadjusted	0.68 (0.55, 0.83)	1.4 × 10-4	1,307	1,941
	unadjusted (only cases with ER status)	0.65 (0.51, 0.84)	1.1 × 10-3	791	1,360
	adjusted for ER status	0.68 (0.52, 0.89)	0.0050	791	1,360
	ER+ only	0.68 (0.55, 0.84)	5 × 10-4	709	985
rs554219
Low/intermediate grade vs controls		1.32 (1.18, 1.48)	8.2 × 10-7	1,465		35,521
High grade vs controls		1.02 (0.91, 1.14)	0.75		1,941	32,202
Case-only high vs low/intermediate grade
	Unadjusted	0.75 (0.65, 0.87)	1.3 × 10-4	1,307	1,941
	unadjusted (only cases with ER status)	0.75 (0.63, 0.88)	2.1 × 10-4	791	1,360
	adjusted for ER status	0.80 (0.67, 0.96)	0.019	792	1,360
	ER+ only	0.76 (0.65, 0.89)	6.7 × 10-4	709	985

OR odds ratio, ER estrogen receptor