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. 2016 Feb 16;9:7. doi: 10.1186/s13072-016-0055-7

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© Liu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — ERβ binds to regions around DMPs. a ERβ recruitment to differentially methylated genes in MEFs (left panel) and ESCs (right panel). HA-tagged ERβ was precipitated and differentially methylated regions were analysed by qRT-PCR. Asterisk indicates significant (p < 0.05) differences between wt/βerkohERβ and βerko MEFs or significant (p < 0.05) enrichment compared to binding at an unrelated, heterochromatic region on chromosome 2 [13] (means + SD; n ≥ 3). b Venn diagram visualising the enriched transcription factor binding motifs around hypo- or hypermethylated DMPs or both. Motifs that have been seen enriched in ERβ-ChIP-seq studies or that are bound by transcription factors known to interact with ERs are depicted in bold