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. 2016 Feb 16;9:7. doi: 10.1186/s13072-016-0055-7

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© Liu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — TDG regulates genes associated with DMPs in ESCs. a Venn diagram showing the overlap of hypo- and hypermethylated DMPs in βerko MEFs identified by RRBS with datasets for 5fC enrichment in deficient (Tdg ^−/−) or proficient (Tdg ^fl/fl) ESCs [16] using GenomeInspector (Genomatix). Hypo and hyper refer to the hypo- and hypermethylated regions identified in this study, respectively. b Enrichment (log2 ratios of observed over random) of 5fC in deficient (Tdg ^−/−) or proficient (Tdg ^fl/fl) ESCs at differently methylated positions. c TDG dependency of differentially methylated genes in ESCs. Gene expression in TDG-deficient (Tdg ^−/− pvector) and TDG-complemented (Tdg ^−/− pTDG) cells was assessed by qRT-PCR (means + SD; n = 3). Asterisk indicates significant (p < 0.05) increase in TDG-proficient vs. TDG-deficient cells