Table 1.
Metabolomic profiles in diabetic embryopathy
| Name | M/Z | RT | FC (DM/ND) | p-value | Mode |
|---|---|---|---|---|---|
| Glycoursodeoxycholic acid | 450.3566 | 380.1778 | 4.9155 | 0.0303 | Positive |
| CE(20:3(8Z,11Z,14Z)) | 675.6755 | 556.3150 | 4.3483 | 0.0487 | Positive |
| Cer(d18:1/26:1(17Z)) | 676.6788 | 556.3023 | 4.2716 | 0.0491 | Positive |
| Geranylgeranylcysteine | 408.3078 | 504.8262 | 4.1764 | 0.0129 | Positive |
| Cholic acid | 409.3107 | 504.9104 | 4.0164 | 0.0118 | Positive |
| TG(24:1(15Z)/24:0/o-18:0) | 1044.6090 | 504.1836 | 3.7078 | 0.0261 | Negative |
| Cepanone | 211.1700 | 504.8546 | 3.6538 | 0.0161 | Positive |
| Geranylgeranylcysteine | 408.3084 | 138.7383 | 3.5957 | 0.0157 | Positive |
| PE(18:3/P-16:0) | 698.6586 | 241.0325 | 3.5759 | 0.0488 | Positive |
| Orotic acid | 156.9953 | 724.6285 | 3.4963 | 0.0317 | Positive |
| Lysyl-Proline | 244.1866 | 504.2698 | 3.3884 | 0.0110 | Positive |
| Metanephrine | 198.1859 | 503.9074 | 3.3789 | 0.0296 | Positive |
| N-Arachidonoyl glycine | 362.3021 | 137.1551 | 3.0794 | 0.0258 | Positive |
| Acetomenaphthone | 259.0975 | 46.1024 | 2.9574 | 0.0264 | Positive |
| Leucyl-Proline | 229.1929 | 504.1836 | 2.9560 | 0.0493 | Positive |
| PIP2(20:4/18:1(11Z)) | 1045.6037 | 502.9756 | 2.9042 | 0.0461 | Positive |
| Cysteinyl-Asparagine | 236.1623 | 506.7862 | 2.8581 | 0.0404 | Positive |
| Thiamine | 266.1833 | 136.5271 | 2.6693 | 0.0400 | Positive |
| SM(d18:0/12:0) | 651.4778 | 248.2837 | 0.3489 | 0.0359 | Positive |
| Melitin | 903.1448 | 517.2036 | 0.3039 | 0.0418 | Positive |
| PGP(18:0/20:3) | 881.1298 | 526.6806 | 0.3018 | 0.0377 | Positive |
| (2E)-Dodecenoyl-CoA | 944.6834 | 806.9919 | 0.2975 | 0.0484 | Positive |
| PI(22:4/18:0) | 915.6454 | 489.3901 | 0.2765 | 0.0437 | Negative |
| PE(15:0/14:0) | 650.4675 | 248.2485 | 0.2719 | 0.0208 | Negative |
| PC(24:0/P-18:0) | 859.1142 | 537.1303 | 0.2698 | 0.0340 | Positive |
| TG(14:1(9Z)/22:5/20:4) | 899.6532 | 817.4480 | 0.2564 | 0.0360 | Positive |
| PE(24:0/24:0) | 916.6511 | 490.5900 | 0.2475 | 0.0466 | Positive |
| PC(22:0/24:1(15Z)) | 928.1835 | 865.1219 | 0.2460 | 0.0410 | Positive |
| PC(16:1(9Z)/24:0) | 844.5977 | 417.0910 | 0.2433 | 0.0288 | Positive |
| TG(18:1(9Z)/15:0/o-18:0) | 834.1120 | 829.4199 | 0.2429 | 0.0374 | Positive |
| TG(24:1(15Z)/18:1(9Z)/22:2) | 1024.2350 | 829.3107 | 0.2251 | 0.0249 | Positive |
| TG(20:4/20:2n6/22:6) | 965.6926 | 798.0809 | 0.2161 | 0.0314 | Positive |
| TG(18:2/20:3n6/20:4) | 943.6815 | 807.3675 | 0.2102 | 0.0225 | Positive |
| TG(22:4/20:5/20:4) | 977.1785 | 373.3367 | 0.2062 | 0.0447 | Positive |
| PC(24:1(15Z)/20:3) | 894.6373 | 506.1557 | 0.2046 | 0.0439 | Positive |
| TG(18:4/20:5/20:4) | 921.6669 | 812.4027 | 0.2037 | 0.0254 | Positive |
| PGP(16:0/16:1(9Z)) | 801.0729 | 433.9451 | 0.1938 | 0.0288 | Positive |
| (3′-sulfo)Galbeta-Cer(d18:0/22:0(2OH)) | 880.6211 | 396.0516 | 0.1806 | 0.0319 | Positive |
| TG(22:4/24:0/o-18:0) | 1010.2210 | 749.1838 | 0.1791 | 0.0179 | Positive |
| TG(14:1(9Z)/15:0/20:5) | 810.0757 | 334.0019 | 0.1787 | 0.0287 | Positive |
| PGP(18:1(9Z)/20:3) | 879.6190 | 396.0207 | 0.1769 | 0.0394 | Positive |
| TG(22:0/18:1(11Z)/o-18:0) | 932.6513 | 386.7160 | 0.1643 | 0.0318 | Positive |
| PC(20:0/22:4) | 866.6123 | 408.3092 | 0.1604 | 0.0152 | Positive |
| Triiodothyronine glucuronide | 828.0993 | 547.1272 | 0.1549 | 0.0345 | Positive |
| TG(18:4/20:5/18:4) | 893.6341 | 504.7999 | 0.1480 | 0.0229 | Positive |
| PC(24:1(15Z)/24:1(15Z)) | 955.1662 | 379.9027 | 0.1478 | 0.0209 | Positive |
| Salicyl CoA | 886.1400 | 671.3439 | 0.1466 | 0.0194 | Positive |
| TG(24:0/22:0/o-18:0) | 1018.2164 | 567.8181 | 0.1199 | 0.0156 | Positive |
| PIP(16:1(9Z)/18:0) | 889.1267 | 399.8242 | 0.1180 | 0.0213 | Positive |
| TG(22:0/22:1/18:3) | 996.2041 | 584.8505 | 0.1119 | 0.0211 | Positive |
| TG(18:4/14:0/22:6) | 871.6229 | 519.4851 | 0.1041 | 0.0114 | Positive |
| 3-Oxooctanoyl-CoA | 908.1547 | 650.9502 | 0.1022 | 0.0135 | Positive |
| TG(20:0/22:5/18:3) | 959.6771 | 466.3990 | 0.0993 | 0.0227 | Positive |
| PG(16:1/18:3) | 743.0342 | 352.9815 | 0.0953 | 0.0197 | Negative |
| TG(18:1/22:1/o-18:0) | 930.1656 | 632.2212 | 0.0913 | 0.0075 | Negative |
| OPC4-CoA | 988.2058 | 768.9839 | 0.0802 | 0.0104 | Positive |
| (S)-3-Hydroxydodecanoyl-CoA | 966.1959 | 797.8451 | 0.0768 | 0.0116 | Positive |
| TG(24:0/18:0/18:1(11Z)) | 974.1922 | 599.4445 | 0.0672 | 0.0118 | Positive |
| Octanoyl-CoA | 894.1380 | 505.3860 | 0.0641 | 0.0151 | Positive |
| (S)-Hydroxydecanoyl-CoA | 938.1642 | 478.7701 | 0.0580 | 0.0242 | Positive |
| TG(22:0/22:4/o-18:0) | 982.1895 | 454.2675 | 0.0579 | 0.0349 | Positive |
| PG(20:3/22:2) | 853.5988 | 321.2533 | 0.0576 | 0.0205 | Positive |
| TG(18:1(11Z)/22:1(13Z)/20:4) | 963.1634 | 298.0084 | 0.0568 | 0.0454 | Positive |
| PC(P-18:1(9Z)/18:4) | 765.0458 | 345.7993 | 0.0567 | 0.0298 | Positive |
| TG(15:0/o-18:0/18:0) | 836.0951 | 417.6578 | 0.0556 | 0.0171 | Positive |
| TG(14:0/18:0/o-18:0) | 822.0772 | 333.9968 | 0.0527 | 0.0495 | Positive |
| TG(14:0/22:0/22:1(13Z)) | 946.1623 | 368.8135 | 0.0509 | 0.0422 | Positive |
| TG(20:4/22:1/o-18:0) | 952.1783 | 617.0061 | 0.0496 | 0.0102 | Positive |
| PE(P-16:0/22:5) | 750.5430 | 274.8144 | 0.0492 | 0.0499 | Positive |
| PIP(20:3/16:0) | 941.1504 | 302.3774 | 0.0469 | 0.0495 | Positive |
| TG(20:5/16:1(9Z)/20:5) | 897.6255 | 311.8055 | 0.0445 | 0.0383 | Positive |
| TG(22:1(13Z)/18:4/o-18:0) | 924.1475 | 377.3902 | 0.0431 | 0.0378 | Positive |
| SM(d16:1/24:1(15Z)) | 787.0600 | 340.0357 | 0.0368 | 0.0256 | Positive |
| PC(24:1(15Z)/22:5) | 919.1381 | 307.0278 | 0.0336 | 0.0360 | Negative |
| PE(22:6/24:1(15Z)) | 874.6095 | 316.4193 | 0.0327 | 0.0329 | Negative |
| PC(20:2/24:1(15Z)) | 896.6226 | 311.8084 | 0.0299 | 0.0344 | Negative |
| PI(16:0/16:1(9Z)) | 809.0733 | 333.4410 | 0.0189 | 0.0212 | Positive |
| PS(14:1(9Z)/14:1(9Z)) | 676.3967 | 178.1948 | 0.0097 | 0.0463 | Positive |
Cer, ceramide. DM, diabetic. FC, fold change. M/Z, mass-to-charge ratio. ND, non-diabetic. PA, phosphatidic acid. PC, phosphatidylcholines. PE, phosphatidylethanolamine. PG, phosphatidylglycerol. PGP, phosphatidylglycerolphosphate. PI, phosphatidylinositol. PIP, phosphatidylinositol phosphate. PS, phosphatidylserine. RT, retention time. SM, sphingomyelin. TG, triglyceride.