Figure 5.

Structural conservation over the Sm fold. (a) Superposition of the C^α trace of all seven Sm proteins, with helix H1 coloured dark red and the β-strands in shades of cyan and green. A dashed circle indicates the C^α position of the conserved hydrophobic residue in H1. (b) The side chain-to-side chain contacts between the conserved residue in H1 and other conserved residues within the hydrophobic belt. This example shows contacts between Leu11 (in a dashed circle) in H1 of SmF and other residues of SmF (brown) and SmE (yellow).