Figure 2.

Sequence conservation of LukE and LukD with other bicomponent pore-forming toxins. The residues in each column of the multiple sequence alignment are colored according to the equivalent (in red) or to the conservation of the physical-chemical properties. The bars in blue, yellow and red indicate the regions belonging to the cap, the stem and the rim, respectively. Loops L3 and L4 and the divergent region DR5 are also indicated.