Table 4. Correlation analysis and multivariate linear regression analysis for changes in PWV.
ΔbaPWV0-6mo |
ΔhaPWV0-6mo |
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---|---|---|---|---|---|---|---|---|
Correlation coefficient | P value | Multivariate regression, adjusted R2 = 0.514 |
Correlation coefficient | P value | Multi-variable regression, adjusted R2 = 0.618 |
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β (95% C.I) | P value | β (95% C.I) | P value | |||||
Age, years | 0.051 | 0.61 | 0.114 | 0.277 | ||||
Gender | 0.113 | 0.697 | -0.027 | 0.801 | ||||
LVH | −0.176 | 0.114 | −0.169 | 0.139 | ||||
Hypertension history, years | −0.094 | 0.352 | 0.02 | 0.848 | ||||
No. of anti-hypertensive medication | −0.19 | 0.853 | −0.013 | 0.9 | ||||
Use of ACEI | −0.029 | 0.775 | 0.026 | 0.807 | ||||
Use of clonidine | −0.73 | 0.464 | −0.053 | 0.614 | ||||
Potassium, mmol/L | 0.035 | 0.73 | 0.041 | 0.696 | ||||
Creatinine, mg/dL | −0.032 | 0.754 | 0.079 | 0.453 | ||||
Log PAC | −0.221 | 0.026 | −0.194 | 0.062 | ||||
Log PRA | −0.015 | 0.879 | 0.082 | 0.44 | ||||
Log ARR | 0.015 | 0.905 | −0.097 | 0.462 | ||||
SBP, mmHg | −0.272 | 0.006 | −0.267 | 0.01 | ||||
DBP, mmHg | −0.274 | 0.005 | −0.281 | 0.006 | ||||
PWVpre# | −0.5 | <0.001 | −0.292 (−0.404~ −0.179) | <0.001 | −0.525 | <0.001 | −0.242 (−0.373~ −0.111) | <0.001 |
ΔLog PAC0-6mo | 0.229 | 0.032 | 0.282 | 0.012 | ||||
ΔLog PRA0-6mo | −0.156 | 0.15 | −0.239 | 0.035 | −23.718 (−43.297~ −4.14) | 0.018 | ||
ΔLog ARR0-6mo | 0.088 | 0.515 | 0.162 | 0.231 | ||||
ΔSBP0-6mo | 0.579 | <0.001 | 0.692 | <0.001 | ||||
ΔDBP0-6mo | 0.597 | <0.001 | 9.137 (6.279~11.996) | <0.001 | 0.742 | <0.001 | 5.781 (4.309~7254) | <0.001 |
Values are mean ± SD. ΔbaPWV0-6mo = the decrease in baPWV at 6 months; ΔhaPWV0-6mo = the decrease in haPWV at 6 months; BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; ACEI = angiotensin converting enzyme inhibitor; LVH = left ventricular hypertrophy; Log PAC = log-transformed plasma aldosterone concentration; Log PRA = log-transformed plasma renin activity; Log ARR = log-transformed aldosterone to renin ratio; ΔLog PAC0-6mo = log-transformed the decrease in plasma aldosterone concentration at 6 months; ΔLog PRA0-6mo = log-transformed the decrease in plasma renin activity at 6 months; ΔLog ARR0-6mo = log-transformed the decrease in aldosterone to renin ratio at 6 months; ΔLog SBP0-6mo = log-transformed the decrease in systolic blood pressure at 6 months; ΔLog DBP0-6mo = log-transformed the decrease in diastolic blood pressure at 6 months; # PWVpre represents baPWVpre in ΔbaPWV0-6mo analysis and haPWVpre in ΔhaPWV0-6mo analysis.