Figure 8. Clinical relevance of common ZEB1/YAP target genes.

(a) Kaplan–Meier plots representing the probability of cumulative relapse-free (RFS) or overall survival (OS) in the same breast cancer set as in b (GSE18229) stratified according to the expression status of the top 8 genes of the ‘common ZEB1/YAP target gene set' (including AXL, LHFP, SERPINE1, SLIT2, DAB2, FSTL1, THBS1, CTGF) in their primary tumours. The log-rank test P value reflects the significance of the correlation between gene set high and shorter survival outcome. (b) Kaplan–Meier plots from meta-analyses showing relapse-free survival (RFS), relapse-free survival after adjuvant chemotherapy and distant metastasis-free survival (DMFS) of ER⁻/PR⁻ breast cancers based on expression of the indicated genes. Note the inverse behaviour of the ‘common ZEB1/YAP top 8 target set' and the ‘YAP only top 3 target set‘ (including HMMR, BIRC5, GGH), particularly for DMFS. For Kaplan–Meier plots, the log-rank test was applied.