Table 3.
Exploratory Behavior in mGlu4, mGlu7, and mGlu8 Knockout and Wild-Type Mice
| Task | Variable | Wild-Type | mGlu4 -/- | mGlu7 -/- | mGlu8 -/- |
|---|---|---|---|---|---|
| OF | Path length (in cm) | 3969(129) | 3567(136) | 3823(251) | 4064(209) |
| Rearing | 32.1(2.9) | 40(6) | 16.2(2.3) | 29.7(2.6) | |
| % path length centre | 25.4(0.9) | 25.4(1.4) | 23.8(2.2) | 23.0(1.5) | |
| SE | Path length (in cm) | 4093.36(125) | 3349(224)* | 3815(298) | 4225(190) |
| Rearing | 37.6(2.3) | 32(4) | 21(4)** | 45.4(2.7) | |
| % path length centre | 49.3(2.4) | 44(4) | 40(6) | 52.1(2.4) | |
| EPM | Total beam crossings | 135(3) | 135(6) | 134(8) | 143(6) |
| Open arm dwell % | 18.7(1.0) | 21.9(1.3) | 19.9(1.5) | 17.3(2.5) |
Abbreviations: EPM, elevated plus maze; OF, open field; SE, social exploration. Data are means (SEM). Asterisks indicate significant difference with wild-type animals: *P<.05; **P<.01.