Table 1.
In Vivo Electrophysiological Properties of Dorsal Raphe (DR) Neurons Recorded under Basal Conditions in Wild-Type (WT) and G-Protein Inwardly Rectifying Potassium (GIRK2) Mutant Mice
| WT (n=86) | GIRK2 +/- (n=79) | GIRK2 -/- (n=45) | WT TPN-Q (n=15) | |
|---|---|---|---|---|
| Firing rate (Hz) | 1.68±0.08 | 1.88±0.09 | 1.99±0.15* | 2.33±0.27** |
| Coefficient of variation (%) | 37.64±1.21 | 36.57±1.21 | 35.21±1.54 | 40.38±3.25 |
| Burst firing neurons (%) | 7 | 5 | 2 | 13 |
| - Firing rate (Hz) | 2.22±0.36 | 2.01±0.37 | 4.03 | 1.49±0.38 |
| - Number of bursts | 1.33±0.21 | 4.33±1.85 | 1.00 | 2.5±1.50 |
| - Spikes in burst (%) | 1.15±0.46 | 1.01±0.87 | 0.41 | 2.8±1.32 |
| - Mean spikes per burst | 3.00±0.81 | 2.00 | 2.00 | 3.50±0.50 |
Abbreviations: GIRK2+/-, GIRK2 heterozygous mice; GIRK2-/-, GIRK2 homozygous mice; WT, wild type; WT TPN-Q, tertiapin-Q-injected wild-type mice.
*P<.05 and **P<.01 vs WT. Unpaired 2-tailed t-test.
Each cell was recorded for at least 3 minutes (180 seconds were taken for subsequent analysis). All data are presented as the mean±SEM of n experiments.