Fig. 5.

Footprint of fragment-2 on the protease domain in mode 1 and 2 structures. Surface representation of various prothrombin/fragment structures showing surfaces within the protease domain that interact with F2. Thrombin is shown in blue; prethrombin-2 is shown in pink; meizothrombin is shown in cyan; prethrombin-1 is shown in magenta; prothrombin from 4NZQ is shown in gray, and from 4HZH is shown in orange. Residues within 3.5 Å of F2 in each structure have been colored yellow with important basic residues of the catalytic domain labeled.