Fig. 6.

Interaction diagram of modes 1 and 2. The interactions between the second kringle domain (F2) and the protease domain (Pro) are shown for the enzyme-like mode 1 and the zymogen-like mode 2. The schematic illustrates that conservation of interactions within modes. Three structures for each mode are represented (Mode 1: 2HPQ solid black lines, 3E6P dashed black lines, 3K65 dotted black lines; Mode 2: 4NZQ solid black lines, 4HZH dashed black lines, 3NXP dotted black lines).