Fig. 7.

Conformational rearrangement of the linker after Arg320 cleavage. The linker between the F2 domain and the protease domain of bovine meizothrombin (PDB:1A0H) is shown as yellow cartoon. Arg271 is shown yellow sticks. The protease domain is displayed as a surface representation and the F2 domain is displayed in red as cartoon (mode 1). The F2 binding in prethrombin-1 is shown as green cartoon (mode 2). The F2 domain bound in mode 1 sterically blocks the linker of in the zymogen conformation (mode 2).