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. 2015 Oct 12;44(3):1105–1117. doi: 10.1093/nar/gkv1038

Figure 2.

Figure 2.

Exemplary tumors showing remarkable association with clinical, pathological and molecular parameters. (A) KICH tumors higher CGI methylation are related with advanced pathological stage, high grade, chromosome 9 loss, high mutation rate, SETD2 and BAP1 mutations, and low activities of FoxM1, Aurora B and PLK1 pathways. (B) STAD tumors with higher CGI methylation are related with high histological grade, high microsatellite instability (MSI-H), gains of 9p and 19p, high mutation rate, PIK3CA and ARID1A mutations, and low activities of p75NTR, Reelin and Ret pathways. (C) STAD tumors with lower backbone methylation are associated with low histological grade, non-diffuse type, low pathological stage, higher number of somatic copy number alterations (SCNAs), loss of 19p and 5q11, gain of 1q21, TP53 mutation, and low activities of c-Kit, FoxM1 and p53 pathways. (D) In LGG, backbone demethylation is associated high histological grade, astrocytoma histology, temporal lobe location, high number of SCNAs, loss of chromosome 10, gain of chromosome 7, EGFR and PTEN mutations, and low activities of BMP receptor, Ret and EGFR pathways.