Table 1. ICL-induced mutation spectra in XPA-proficient and -deficient human cells in the presence or absence of HMGB1.

	Base substitution	Insertion	Deletion
XPA+/+	75% (15/20)	0% (0/20)	25% (5/20)
XPA−/−	75% (15/20)	0% (0/20)	25% (5/20)
HMGB1 KD
XPA+/+	75% (15/20)	0% (0/20)	45% (9/20)*
XPA−/−	70% (14/20)	5% (1/20)	50% (10/20)*

*Clones containing more than one mutation.

n = 20; mutants sequenced from three independent experiments.

The percentages shown have been calculated as mutations per plasmid sequenced.