Table 2. ICL-induced transversions in XPA-proficient and -deficient human cells in the presence or absence of HMGB1.

Transversions	XPA+/+	XPA−/−	XPA+/+ (HMGB1-depleted)	XPA−/− (HMGB1-depleted)
			HMGB1 depleted
T→A	45%* (9/20)	30% (6/20)	35% (7/20)	15% (3/20)
T→G	10% (2/20)	15% (3/20)	15% (3/20)	45% (9/20)

*Bold font highlights the predominant transversion event.

n = 20; mutants sequenced from three independent experiments.

The percentages shown have been calculated as mutations per plasmid sequenced.