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Effects of manganese on nucleotide incorporation and transcription fidelity. (A) Scheme of the reaction with the minimal nucleic acid scaffold. (B) Kinetics of cognate UTP addition (1 mM, 10°C) by Eco and Dra RNAPs in the presence of magnesium or manganese ions. The plot shows accumulation of the 9 nt RNA product over the reaction time (normalized to the maximal extension for each reaction). (C) Kinetics of non-cognate CTP addition (1 mM, 25°C).
