Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neurobiol Aging. 2015 Aug 29;36(12):3130–3139. doi: 10.1016/j.neurobiolaging.2015.08.022

Figure 1. BDNF mRNA and protein expression in BA7.

Figure 1

A: BDNF mRNA expression is decreased in demented subjects, regardless of pathology. Demented subjects (D/P+D/NP, n=24) compared to not demented (ND/NP+ND/P, n=26, two-tailed Student t-test, p=0.014). B: Trend towards significant differences between the four clinicopathologic groups broken down by cognition and pathology (one-way ANOVA, p=0.1). Clinicopathologic groups: (1) ND/NP, not demented with no pathology, control group, n=13, (2) ND/P, not demented with pathology, n=13 (protein n=14), (3) D/NP, demented with no pathology, n=9, (4) D/P, demented with pathology, typical AD, n=15. C: No difference between groups in level of BDNF protein (one-tailed Student t-test, p=0.11). Horizontal bars represent the group mean. D: Highly significant correlation of BDNF mRNA with BDNF protein (Pearson correlation, r=0.658, p<0.001).