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Tau antibodies used in this study and their epitopes.
| Antibody | Epitope* |
|---|---|
| 39E10 | 189-195, proline-rich domain |
| Tau5 | 210-230, proline-rich domain |
| Tau12 | 2-23, N-terminus |
| Tau46 | 404-441, C-terminus |
| p-Thr181 | Tau phosphorylated at Thr181 |
| p-Thr231 | Tau phosphorylated at Thr231 |
| p-Ser203 | Tau phosphorylated at Ser203 |
Epitope numbering is according to the longest CNS tau isoform 2N4R.
Antibodies 39E10 and p-Thr181 (BOLD) were used for measurements of immunoreactive tau bands in all samples.
