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. Author manuscript; available in PMC: 2016 Mar 25.
Published in final edited form as: Methods Enzymol. 2015 Mar 25;558:39–73. doi: 10.1016/bs.mie.2015.02.002

Figure 1.

Figure 1

Secondary structural changes in RNA (A) Adenine riboswitch secondary structure with and without the adenine metabolite, which binds to the aptamer domain stabilizing a specific secondary structure turning on transcription. In the absence of metabolite the Shine-Dalgarno sequence (blue) is sequestered turning off transcription (Reining, A. et al., 2013). (B) Secondary structural transitions of mRNA (dashed line) and a spliceosome catalyzed by chaperones (DExD or H-box helicases) that are key for splicing. (C) pH dependent secondary structural equilibrium in the murine leukaemia virus pseudoknot (MLV-PK) mRNA that regulates translational miscoding.