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. Author manuscript; available in PMC: 2016 Mar 25.
Published in final edited form as: Methods Enzymol. 2015 Mar 25;558:39–73. doi: 10.1016/bs.mie.2015.02.002

Figure 2.

Figure 2

HIV-1 TAR exists in dynamic equilibrium with two excited states (ES1 and ES2). Shown are the ES secondary structure, population (pES), lifetime (τ), as well as the forward (k1/k2) and reverse (k−1/k−2) rate constants. The GS is labeled to show sites with slow (red), fast (green) and no chemical change (black) measured by R1ρ relaxation dispersion. Note that A35 shows a combination of fast (C1′) and slow (C8) exchange. Sites in grey were not measured due to spectral overlap.