Table 1. Urine Chemistry.
Parameters | Normal control | Induction control | Treatment groups | ||||
---|---|---|---|---|---|---|---|
STS alone | Diazoxide alone | Glibenclamide alone | Diazoxide+STS | Glibenclamide+STS | |||
Urea (mg/mL) | 11.12±0.9 | 6.06 ±1.2* | 9.07±1.3 | 10.77±1.5 | 7.33±0.8* | 8.92±1.3 | 10.29±1.5 |
Creatinine (µm/L) | 12.13±1.4 | 6.26±1.5* | 9.42±0.4 | 8.99±2.9 | 3.94±0.2* | 6.93±1.8* | 7.24±1.5* |
Calcium (mg/24hr) | 0.95±0.1 | 2.44±0.2* | 1.10±0.3 | 0.69±0.1* | 1.23±0.3 | 1.28±0.2 | 0.60±0.1* |
Group-1 = served as normal control; Group-2 = as a stone induction control; Group-3 = was given STS; Group-4 and Group-5 = were administered diazoxide and glibenclamide respectively and Groups 6 and 7 = were pretreated with diazoxide and glibenclamide respectively half an hour before administration of STS. Data of all results are presented as mean±SD (*) p<0.05, statistically different from normal controls.