Table 2. serum Chemistry.
Parameters | Normal control | Induction control | Treatment groups | ||||
---|---|---|---|---|---|---|---|
STS alone | Diazoxide alone | Glibenclamide alone | Diazoxide +STS | Glibenclamide +STS | |||
Urea (mg/dL) | 16.50±0.9 | 41.94±1.1* | 18.76±1.2 | 19.55±1.3 | 29.93±1.2* | 16.42±1.6 | 13.74±1.3 |
Creatinine (mg/ dL) | 0.35±0.02 | 1.03±0.07* | 0.38±0.02 | 0.35±0.06 | 0.58±0.02* | 0.38±0.04 | 0.35±0.06 |
ALP (U/L) | 57.03±2.3 | 115.96±2.9* | 49.25±2.4 | 50.73±3.2 | 76.18±2.4* | 70.14±4.2* | 41.39±2.1 |
Calcium (mg/dL) | 6.21±0.5 | 5.14±0.9 | 4.46±0.7* | 3.34±0.7* | 1.57±0.2* | 4.31±0.7* | 4.10±0.9* |
Group-1 = served as normal control; Group-2 = as a stone induction control; Group-3 = was given STS; Group-4 and Group-5 = were administered diazoxide and glibenclamide respectively and Groups 6 and 7 were pretreated with diazoxide and glibenclamide respectively half an hour before administration of STS. Data of all results are presented as mean±SD (*) p<0.05, statistically different from normal controls.