Table 3. Lipid peroxidation and antioxidant levels.
Parameters | Normal control | Induction control | Treatment groups | ||||
---|---|---|---|---|---|---|---|
STS alone | Diazoxide alone | Glibenclamide alone | Diazoxide +STS | Glibenclamide +STS | |||
TBARS (mM/100g tissue) | 1.78±0.1 | 4.21±0.5* | 2.10±0.4 | 0.84±0.09* | 0.74±0.05* | 0.71±0.03* | 0.72±0.08* |
Superoxide Dismutase (Units/mg protein) | 34.7±4.5 | 17.64±1.2* | 31.24±2.4 | 26.47±1.2* | 25.63±1.3* | 29.91±2.3 | 32.30±2.6 |
Glutathione peroxidase (µg of GSH utilized/min/ mg protein) | 22±1.2 | 12.13±1.1* | 19.14±1.6 | 15.54±1.3* | 16.66±1.5* | 19.82±1.1 | 19.57±1.4 |
Group-1 = served as normal control; Group-2 = as a stone induction control; Group-3 = was given STS; Group-4 and Group-5 = were administered diazoxide and glibenclamide respectively and Groups 6 and 7 = were pretreated with diazoxide and glibenclamide respectively half an hour before administration of STS. Data of all results are presented as mean±SD (*) p<0.05, statistically different from normal controls.