Table 2.
Top signals of logistic regression (P < 10−4) without adjustment
| SNP | Chr | Base Pair Position | Minor Allele | MAF | Selection Category | Host Gene | OR (95% CI) | P Value |
|---|---|---|---|---|---|---|---|---|
| rs2301753 | 6 | 30147219 | A | 0.117 | WHR | RNF39 | 0.40 (0.28, 0.57) | 7.26E-07 |
| chr17:30331990 | 17 | 30331990 | A | 0.053 | QT | LIG3 | 2.41 (1.68, 3.47) | 1.91E-06 |
| chr15:61195932 | 15 | 61195932 | A | 0.040 | HDL | intergenic | 2.64 (1.76, 3.96) | 2.73E-06 |
| rs8095193 | 18 | 58834095 | A | 0.222 | QT | intergenic | 1.60 (1.30, 1.96) | 7.33E-06 |
| rs550338 | 12 | 24403304 | A | 0.238 | T2D | SOX5 | 0.61 (0.48, 0.76) | 1.16E-05 |
| rs11657937 | 17 | 56508571 | A | 0.063 | SBP | BCAS3 | 2.01 (1.47, 2.75) | 1.18E-05 |
| rs12818945 | 12 | 88542365 | A | 0.047 | DBP | ATP2B1 | 2.19 (1.53, 3.13) | 1.84E-05 |
| rs9379976 | 6 | 27406179 | G | 0.236 | MHC | intergenic | 1.53 (1.25, 1.87) | 3.18E-05 |
| rs17532886 | 16 | 50026847 | G | 0.226 | FG | intergenic | 0.62 (0.50, 0.78) | 3.19E-05 |
| rs2445887 | 5 | 78345800 | A | 0.460 | FG | DMGDH | 0.69 (0.58, 0.83) | 4.78E-05 |
| chr1:160598245 | 1 | 160598245 | G | 0.371 | QT | NOS1AP | 1.45 (1.21, 1.74) | 5.22E-05 |
| rs9266772 | 6 | 31460092 | G | 0.185 | SBP | intergenic | 1.56 (1.26, 1.93) | 5.59E-05 |
| rs2493134 | 1 | 228915982 | G | 0.436 | MICAD | AGT | 0.70 (0.58, 0.83) | 7.91E-05 |
| rs2024366 | 7 | 153663907 | G | 0.326 | SBP | DPP6 | 0.67 (0.55, 0.82) | 8.03E-05 |
| rs7328971 | 13 | 30390640 | A | 0.250 | QT | C13orf33 | 1.48 (1.22, 1.81) | 8.08E-05 |
SNP, single nucleotide polymorphism identifier; Chr, chromosome number; MAF, minor allele frequency; Host gene, gene locus of SNP; OR, odds ratio; 95% CI, 95% confidence interval; P, asymptotic P value for t-statistic. Selection category is the functional annotation of the selected SNP on the Cardio-MetaboChip.
QT, QT interval; T2D, Type 2 diabetes; MHC, major histocompatibility complex; FG, fasting glucose level; MICAD, myocardial infarction and coronary artery diseases.