Table 3.
Top signals of logistic regression (P < 10−4) in WISE and WTH participants adjusted for age, BMI, diabetes, and principal components for ancestral correction
| SNP | Chr | Base Pair Position | Minor Allele | MAF | Selection Category | Host Gene | OR (95% CI) | P Value |
|---|---|---|---|---|---|---|---|---|
| rs12818945 | 12 | 88542365 | A | 0.047 | DBP | ATP2B1 | 2.38 (1.63, 3.45) | 5.82E-06 |
| rs2301753 | 6 | 30147219 | A | 0.117 | WHR | RNF39 | 0.42 (0.29, 0.62) | 8.91E-06 |
| chr17:30331990 | 17 | 30331990 | A | 0.053 | QT | LIG3 | 2.35 (1.60, 3.44) | 1.20E-05 |
| rs17532886 | 16 | 50026847 | G | 0.226 | fastGlu | intergenic | 0.61 (0.48, 0.77) | 3.02E-05 |
| rs3852892 | 19 | 59414407 | A | 0.113 | N/A | intergenic | 1.76 (1.35, 2.31) | 3.85E-05 |
| rs6906489 | 6 | 161573429 | G | 0.047 | DBP | AGPAT4 | 0.27 (0.15, 0.51) | 3.90E-05 |
| chr15:61195932 | 15 | 61195932 | A | 0.040 | HDL | intergenic | 2.41 (1.58, 3.70) | 5.19E-05 |
| rs550338 | 12 | 24403304 | A | 0.238 | T2D | SOX5 | 0.62 (0.49, 0.78) | 5.25E-05 |
| chr1:160598245 | 1 | 160598245 | G | 0.371 | QT | NOS1AP | 1.48 (1.22, 1.78) | 5.56E-05 |
| rs9379976 | 6 | 27406179 | G | 0.236 | MHC | intergenic | 1.54 (1.25, 1.91) | 5.71E-05 |
| rs10503586 | 8 | 16792998 | G | 0.074 | T2D | intergenic | 1.92 (1.40, 2.63) | 5.83E-05 |
| chr12:88382885 | 12 | 88382885 | A | 0.031 | SBP | TUWD12 | 2.53 (1.60, 4.00) | 7.22E-05 |
| rs9266772 | 6 | 31460092 | G | 0.185 | SBP | intergenic | 1.57 (1.25, 1.96) | 8.00E-05 |
| rs12025601 | 1 | 96796873 | A | 0.249 | BMI | intergenic | 1.52 (1.23, 1.87) | 8.36E-05 |
| rs9379977 | 6 | 27406258 | G | 0.235 | MHC | intergenic | 1.53 (1.24, 1.89) | 8.37E-05 |
| rs12889954 | 14 | 63457221 | G | 0.156 | HbA1C | SYNE2 | 1.63 (1.28, 2.09) | 9.17E-05 |
Selection category is the functional annotation of the selected SNP on the Cardio-MetaboChip.
fastGlu, fasting glucose level; HbA1C, hemoglobin A1c.