Table 5.
Top signals of logistic regression (P < 10−4) adjusted for age, BMI, diabetes, principal components for ancestral correction, and DBP
| SNP | Chr | Base Pair Position | Minor Allele | MAF | Selection Category | Host gene | OR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| rs9266772 | 6 | 31460092 | G | 0.185 | SBP | intergenic | 1.67 (1.32, 2.10) | 1.50E-05 |
| rs6906489 | 6 | 161573429 | G | 0.047 | DBP | AGPAT4 | 0.25 (0.13, 0.47) | 1.85E-05 |
| rs3852892 | 19 | 59414407 | A | 0.113 | N/A | intergenic | 1.78 (1.35, 2.35) | 5.18E-05 |
| rs10503586 | 8 | 16792998 | G | 0.074 | T2D | intergenic | 1.99 (1.42, 2.77) | 5.82E-05 |
| rs2301753 | 6 | 30147219 | A | 0.117 | WHR | RNF39 | 0.45 (0.30, 0.67) | 5.95E-05 |
| chr1:160598245 | 1 | 160598245 | G | 0.371 | QT | NOS1AP | 1.49 (1.22, 1.82) | 6.69E-05 |
| rs12818945 | 12 | 88542365 | A | 0.047 | DBP | ATP2B1 | 2.23 (1.50, 3.31) | 6.97E-05 |
| rs12025601 | 1 | 96796873 | A | 0.249 | BMI | intergenic | 1.54 (1.24, 1.92) | 9.10E-05 |
Selection category is the functional annotation of the selected SNP on Cardio-MetaboChip.