Table 2.
Top 20 unique genes associated with muscle strength in the meta-analysis of all participants, with robust replication in Illumina
|
Meta-analysis |
P Values |
||||||
|---|---|---|---|---|---|---|---|
| Z Score | P Value | BH P Value | FHS | Illumina | Gene | EntrezID | Name |
| −5.67 | 1.5 × 10−8 | 2.0 × 10−4 | 3.9 × 10−7 | 9.9 × 10−3 | ALAS2 | 212 | aminolevulinate, delta-, synthase 2 |
| 5.37 | 7.8 × 10−8 | 3.1 × 10−4 | 4.3 × 10−7 | 4.0 × 10−2 | HEATR5A | 25938 | HEAT repeat containing 5A |
| −5.28 | 1.3 × 10−7 | 3.9 × 10−4 | 2.7 × 10−5 | 1.2 × 10−3 | PNP | 4860 | purine nucleoside phosphorylase |
| −5.17 | 2.4 × 10−7 | 4.7 × 10−4 | 1.1 × 10−6 | 5.0 × 10−2 | STOM | 2040 | stomatin |
| 5.14 | 2.8 × 10−7 | 4.7 × 10−4 | 7.9 × 10−6 | 1.1 × 10−2 | RPS6KA5 | 9252 | ribosomal protein S6 kinase, 90 kDa, polypeptide 5 |
| −5.09 | 3.7 × 10−7 | 5.8 × 10−4 | 5.4 × 10−5 | 1.8 × 10−3 | MBNL3 | 55796 | muscle blind-like splicing regulator 3 |
| −5.07 | 3.9 × 10−7 | 5.8 × 10−4 | 2.3 × 10−6 | 4.4 × 10−2 | RAD23A | 5886 | RAD23 homolog A (S. cerevisiae) |
| 5.02 | 5.1 × 10−7 | 6.8 × 10−4 | 7.7 × 10−5 | 1.7 × 10−3 | HNRNPA0 | 10949 | heterogeneous nuclear ribonucleoprotein A0 |
| −4.90 | 9.5 × 10−7 | 1.1 × 10−3 | 2.0 × 10−5 | 1.5 × 10−2 | GID4 | 79018 | GID complex subunit 4 |
| −4.88 | 1.1 × 10−6 | 1.1 × 10−3 | 9.3 × 10−6 | 3.4 × 10−2 | TFDP1 | 7027 | transcription factor Dp-1 |
| 4.80 | 1.6 × 10−6 | 1.4 × 10−3 | 9.9 × 10−6 | 4.7 × 10−2 | ARRDC3 | 57561 | arrestin domain containing 3 |
| −4.77 | 1.7 × 10−6 | 1.5 × 10−3 | 1.8 × 10−5 | 3.3 × 10−2 | RIOK3 | 8780 | RIO kinase 3 |
| −4.71 | 2.5 × 10−6 | 1.8 × 10−3 | 1.9 × 10−5 | 4.1 × 10−2 | NTAN1 | 123803 | NH2-terminal asparagine amidase |
| 4.66 | 3.1 × 10−6 | 2.2 × 10−3 | 8.1 × 10−4 | 6.0 × 10−4 | PDE4D | 5144 | phosphodiesterase 4D, cAMP-specific |
| −4.62 | 3.8 × 10−6 | 2.4 × 10−3 | 1.1 × 10−4 | 1.2 × 10−2 | RGCC | 28984 | regulator of cell cycle |
| 4.61 | 4.1 × 10−6 | 2.5 × 10−3 | 9.6 × 10−5 | 1.4 × 10−2 | POLR2B | 5431 | polymerase (RNA) II (DNA directed) polypeptide B |
| −4.59 | 4.4 × 10−6 | 2.5 × 10−3 | 6.1 × 10−5 | 2.4 × 10−2 | EIF1B | 10289 | eukaryotic translation initiation factor 1B |
| 4.57 | 4.8 × 10−6 | 2.7 × 10−3 | 5.4 × 10−4 | 2.0 × 10−3 | CIRBP | 1153 | cold inducible RNA binding protein |
| −4.57 | 4.8 × 10−6 | 2.7 × 10−3 | 6.2 × 10−5 | 2.7 × 10−2 | ASGR2 | 433 | asialoglycoprotein receptor 2 |
| −4.55 | 5.3 × 10−6 | 2.9 × 10−3 | 3.8 × 10−5 | 4.5 × 10−2 | CA1 | 759 | carbonic anhydrase I |
BH, Benjamini-Hochberg. Ordered by meta-analysis P value. Showing top 20 results with nominal “replication” (P < 0.05) in Illumina. Duplicate gene entries excluded. Full table in Supplementary Table S1.