Table 7.
20 SNPs with smallest P values of pharmacogenetic association (interaction of SNP and treatment) with change in CAC (change in CAC >5 AU) after 4 yr of treatment in women enrolled in KEEPS who completed the study in their treatment group
| OR (95% CI) for Treatment
vs. Placebo (given genotype) Adjusted for Ethnicity and
Baseline CAC >0 AU |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Chr., bp | C/M allele | MAF | E2/CC | E2/CR | E2/RR | CCE/CC | CCE/CR | CCE/RR | P Value |
| rs3802857 | CADM1 | 11/114583828 | C/G | 0.357 | 0.105(0.021,0.513) | 2.01(0.703,5.77) | 38.7(4.73,317) | 0.19(0.038,0.947) | 1.18(0.383,3.61) | 7.27(0.683,77.3) | 2.42E-04 |
| rs2250889 | MMP9* | 20/44075813 | G/C | 0.080 | 0.461(0.156,1.36) | NA | NA | 0.573(0.208,1.58) | NA | NA | 2.87E-04 |
| rs669607 | C3orf68 | 3/28046448 | A/C | 0.439 | 3.21(0.768,13.4) | 0.757(0.283,2.03) | 0.178(0.026,1.24) | 0.026(0.002,0.447) | 0.272(0.072,1.04) | 2.84(0.59,13.7) | 3.54E-04 |
| rs10738763 | TEK | 9/82710576 | A/G | 0.226 | 0.391(0.123,1.25) | 6.44(1.15,36.2) | 106(2.99,3770) | 0.131(0.029,0.596) | 3.82(0.702,20.8) | 111(3.67,3370) | 3.57E-04 |
| rs615375 | TEK | 9/27102311 | A/C | 0.269 | 0.337(0.099,1.14) | 7.86(1.31,47.3) | 184(4.26,7910) | 0.129(0.027,0.622) | 4.56(0.773,26.9) | 161(4.27,6040) | 4.16E-04 |
| rs8083599 | COLEC12 | 18/362837 | C/A | 0.291 | 3.84(1.01,14.6) | 0.456(0.142,1.46) | 0.054(0.005,0.547) | 3.94(0.96,16.2) | 0.224(0.062,0.819) | 0.013(0.001,0.195) | 4.22E-04 |
| rs343321 | PLSCR1 | 3/147716959 | G/A | 0.125 | 0.802(0.287,2.24) | 6.07(0.527,70) | 46(0.327,6470) | 0.191(0.052,0.708) | 19.7(1.71,226) | 2020(12.7,321000) | 6.36E-04 |
| rs11583394 | IL19 | 1/205035516 | A/G | 0.225 | 1.02(0.317,3.25) | 1.16(0.309,4.35) | 1.32(0.0844,20.7) | 1.88(0.593,5.93) | NA | NA | 6.75E-04 |
| rs9276976 | HLA-DOA | 6/33081772 | G/A | 0.148 | 0.274(0.08,0.944) | 10.7(1.97,58.2) | 417(11.4,15200) | 0.413(0.128,1.34) | 2.57(0.36,18.4) | 16(0.275,927) | 6.83E-04 |
| rs1983357 | LOC730057 | 3/64969335 | A/C | 0.223 | 2.24(0.66,7.62) | 0.39(0.099,1.53) | 0.068(0.004,1.15) | 2.6(0.755,8.92) | 0.043(0.004,0.422) | 7.0e-4(6.0e-6,0.082) | 7.84E-04 |
| rs2292483 | TRAF5 | 1/209599650 | A/G | 0.265 | 0.243(0.068,0.87) | 2.95(0.873,9.96) | 35.8(3.07,418) | 0.621(0.189,2.04) | 0.702(0.151,3.25) | 0.792(0.035,18) | 8.31E-04 |
| rs9323910 | SERPINA3† | 14/94158379 | G/C | 0.247 | 4.75(1.35,16.8) | 0.268(0.078,0.917) | 0.015(0.001,0.206) | 1.61(0.394,6.57) | 0.272(0.068,1.08) | 0.046(0.002,0.933) | 8.61E-04 |
| rs4252287 | IL10RA | 11/117373848 | G/A | 0.095 | 1.83(0.672,4.97) | NA | NA | 1.09(0.377,3.17) | NA | NA | 8.63E-04 |
| rs12654778 | ADRB2 | 5/148185934 | G/A | 0.374 | 0.257(0.051,1.29) | 1.15(0.427,3.09) | 5.12(0.84,31.4) | 1.5(0.404,5.58) | 0.307(0.077,1.23) | 0.063(0.004,1.13) | 9.19E-04 |
| rs3794660 | IRF8 | 16/84500669 | C/G | 0.034 | 0.972(0.387,2.45) | 1.42(0,Inf) | NA | 0.35(0.112,1.09) | NA | NA | 1.03E-03 |
| rs10406069 | CD22‡// | 19/40528370 | G/A | 0.157 | 0.507(0.177,1.45) | NA | NA | 0.344(0.104,1.14) | NA | NA | 1.09E-03 |
| rs10191694 | SERPINE22§ | 2/224565510 | C/A | 0.380 | 2.08(0.544,7.92) | 0.805(0.299,2.17) | 0.312(0.046,2.11) | 3.52(0.91,13.6) | 0.083(0.009,0.736) | 0.002(2.2e-05,0.174) | 1.13E-03 |
| rs1042713 | ADRB2 | 5/148186633 | G/A | 0.399 | 0.238(0.048,1.19) | 1.13(0.422,3.03) | 5.36(0.93,30.8) | 1.3(0.351,4.78) | 0.312(0.078,1.25) | 0.075(0.004,1.33) | 1.15E-03 |
| rs13068939 | ITPR1 | 3/4563300 | G/A | 0.257 | 1.42(0.42,4.79) | 0.716(0.199,2.58) | 0.361(0.024,5.51) | 0.115(0.022,0.601) | 1.44(0.467,4.42) | 18(1.85,175) | 1.15E-03 |
| rs894685 | C1QL1 | 17/40410565 | A/G | 0.301 | 0.369(0.101,1.34) | 1.8(0.578,5.61) | 8.8(0.992,78) | 1.35(0.424,4.28) | 0.288(0.052,1.61) | 0.061(0.002,2.03) | 1.18E-03 |
SNP call rate >0.99 for all SNPS.
*
Next to LOC100128028;
†
next to LOC390503;
‡
next to FFAR1;
§
next to LOC100129171.
C/M, common/minor; NA, no results due to small sample size.