Table 3.
Frequency of genotypes and alleles of polymorphisms rs2672598 -487T>C and rs11200638 -625 G>A
| Genotype | AMD cases (n=120) | Controls (n=120) | χ 2 ( p ) | OR p | OR (CI 95%) | |||
|---|---|---|---|---|---|---|---|---|
| Wet (n=88) | Dry (n=32) | |||||||
| rs11200638 -625 G>A | ||||||||
| GG (%) | 11 (12.5%) | 9 (28.1%) | 42 (35%) | 48.56 (<0.001) | --- | 1.0 | ||
| AG (%) | 30 (34.1%) | 12 (37.5%) | 66 (55%) | 0.388 | 1.33 (0.692-2.581) | |||
| AA (%) | 47 (53.4%) | 11 (34.4%) | 12 (10%) | <0.001 | 10.15 (4.47-23.01) | |||
| χ2 HW (p) | 2.88 (0.09) | 1.95 (0.16) | 3.60 (0.06) | |||||
| Allele | ||||||||
| G (%) | 41 (24.8%) | 30 (46.9%) | 150 (62.5%) | 10.52 (0.002) | --- | 1.0 | ||
| A (%) | 124 (75.2%) | 34 (53.1%) | 90 (37.5%) | 0.001 | 2.69 (1.46-4.95) | |||
| rs2672598 -487T>C | ||||||||
| TT | 7 (8%) | 12 (37.5%) | 42 (35%) | 55.42 (<0.001) | --- | 1.0 | ||
| CT | 30 (34%) | 12 (37.5%) | 63 (52.5%) | 0.225 | 1.47 (0.75- 2.87) | |||
| CC | 51 (58%) | 8 (25%) | 15 (12.5%) | <0.001 | 8.69 (3.96- 19.04) | |||
| χ2 HW (p) | 0.72 (0.393) | 1.81 (0.17) | 1.34 (0.24) | |||||
| Allele | ||||||||
| T (%) | 44 (25%) | 36 (56.25%) | 147 (61.25%) | 11.62 (0.001) | --- | 1.0 | ||
| C (%) | 132 (75%) | 28 (43.75%) | 93 (38.75%) | 0.001 | 2.86 (1.54-5.30) | |||