| Positive |
|
|
| Activate |
Leptin in central nervous system exhibit their action by binding to ob-Rb, a long isoform of leptin receptor. The binding leads to the activation of four tyrosine residues by phosphorylation and a Box 1 region in ob-Rb. |
Frühbeck,2006 |
| Positive |
The STAT3 exhibits a positive regulation on POMC [pro-opio melanocortin], which are the major molecules in energy regulation |
Frühbeck, 2006 |
| Induce |
C/EBP β and C/EBP δ induces kruppel-like transcription factor [KLF] 5. |
A. Schäffler et al, 2006 |
| Stimulate |
E2F1 stimulate PPAR γ during early stages and E2F4 inhibit it in later stages. |
Fajas, L. et al, 2002 |
| Up-regulate |
In adipocytes, SORBS1 is upregulated by thiazolidinedione [TZD] through PPAR γ and also interact with insulin receptor. |
Wen-Hsing Lin et al, 2001 |
| Increase |
PRDM16, which leads to increase in expression of UCP1, PGC α and PGC β during mature adipocyte development |
Yu-Hua Tseng et al, 2008 |
| Enhance |
Urocortin enhances Leptin-Induced Stat1 Activation, Mediated by Either CRHR1 or CRHR2. |
Weihong Pan et al,2007 |
| Require |
We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. |
Eduardo R. Ropelle et al, 2010 |
| Bind |
Follistatin binds to myostatin but also binds to and inhibits other members of the TGF-beta superfamily, notably activins. |
Nakatani M et al, 2008 |
| Trigger |
AMPK activated through leptin and external stimuli, triggers myocytes enhancing factor 2 [MEF2] [A & D] which leads to the expression of GLUT4. |
Farid F. Chehab, 2008 |
| Negative |
|
|
| Inhibit |
PPAR γ inhibit the expression of aromatase by CYP19A1 gene. |
Reposo Ramirez-Lorca et al, 2007 |
| Negative |
LXR [liver X receptor], a transcription factor take part in adipogenesis by negatively regulating PGC-1, glucose-6 phosphatase, phosphoenol pyruvate carboxykinase [PEPCK/PCK2]. |
Bryan A. Laffitte et al, 2003 |
| Prevent |
PON3 in plasma individually prevents artherosclerosis by inhibiting phospholipid stimulation of monocyte chemotactic protein [MCP] |
Diana M. Shih et al, 2007 |
| Decrease |
PPAR δ decreases LDL and triglycerides. |
Markku Va¨nttinen et al, 2005 |
| Reduce |
In the presence of ID3, the binding of E47 and SREBP1 is reduced, thereby transcriptional activity of ADIPOQ is controlled. |
Curt D. Sigmund et al, 2008 |
| Suppress |
In conclusion, disruption of neuromedin B receptor did not interfere with the sensitivity of thyroid hormone-mediated suppression of TSH release, but impaired the ability of thyrotroph to increase serum TSH in hypothyroidism, which highlights the importance of NB in modulating the set point of the hypothalamus–pituitary–thyroid axis at hypothyroidism. |
Karen J Oliveira et al,2008 |
| Down-regulate |
We demonstrate that activation of LXR in the liver leads to the induction of glucokinase expression and to the down-regulation of peroxisome proliferator-activated receptor γ coactivator-1α [PGC-1] and genes involved in gluconeogenesis. |
Bryan A. Laffitte et al, 2003 |
| Neutral |
|
|
| Regulate |
The cyclic AMP responsive element–binding protein-1 [Creb1]-regulated transcription coactivator-1 [Crtc1] is required for energy regulation |
Judith Y Altarejos et al, 2008. |
| Correlate |
In girls, visfatin correlated with leptin, r = 0.40, P = 0.009, and thiols, r = -0.36, P = 0.009, which explained 24% in visfatin variability. |
Krzystek-korpacka M et al, 2011 |
| Elicit |
At basal glucose, GIP does not elicit insulin release. |
Pfeiffer AF et al, 2010 |
| Influence |
An exciting new report describes that leptin can influence insulin release by osteoclastin, a hormone produced by osteoblasts. |
Rashmi C and Rodger AL, 2011 |
| Associate |
Leptin was associated with insulin, insulin resistance, and body composition parameters, body mass index, basal metabolic rate, body weight, %fat, and fat mass, in participants, with or without T2DM in both genders. |
Gulturk S et al, 2008 |
| Affect |
In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity. |
Sekiya M et al, 2009 |
| Contribute |
FOXO1 may contribute to enhanced ADIPOR1, but not ADIPOR2 transcription in IR. |
Felder TK et al, 2010 |
| Catalysis |
|
|
| Catalysis |
Tyrosine hydroxylase [TH] catalysis the conversion of L-tyrosine to DOPA which in-turn is regulated by SPOCK1, fgf14 [fibroblast growth factor-14], Cxcl14, BMP6 [bone morphogenetic protein 6] |
C. Vadasza, 2007 |
