Table 3. Describes information of five modules obtained from the network.
Modules | Pre-dominant Molecule | Likely Anatomical Component | Physiological Process | Major Molecules with their degree of connectivity |
---|---|---|---|---|
Module 1 | Leptin | Central Nervous System | Satiety, Appetite, Energy expenditure | Leptin [LEP]– 14, Dopamine– 9, Catecholamine– 8,Ghrelin—Growth Hormone Segretagogue Receptor[GH-GHSR]-5, Agouti-related Protein [AGRP]– 8, Pro-opiomelanocortin [POMC]– 6, NeuroPeptide Y [NPY]– 7,Tyrosine Hydroxylase—4, Adregenic Receptor Alpha 1B [ADRA1B]-3 |
Module 2 | Insulin | Pancreas | Glucose metabolism | Insulin [INS]– 21,Forkhead box A2 [HNF3B]– 6,Pancreatic and Duodenal Homeobox 1 [PDX1]– 7,Forkhead box O1[FOXO1]– 6,Interleukin 6 [IL6]– 5 Leptin [LEP]– 5,Insulin receptor substrate 1 [IRS1]– 6, Insulin receptor substrate 2[IRS2]– 5,Insulin receptor– 5 |
Module 3 | High Density lipoprotein | Liver & Gastro-Intestinal Tract | Fatty acid regulation and metabolism, Base-line glucose control. | Lipoprotein Lipase[LPL]– 6,High Density Lipoprotein– 12,Low Density Lipoprotein– 6,FXR alpha– 5,Cholesterol– 6 |
Module 4 | PPAR gamma | Adipose Tissue | Store fat derived from the diet and liver metabolism or degrades stored fat to supply fatty acids and glycerol to the circulation. | Peroxisome proliferator-activated receptor PPAR alpha– 9,PPAR gamma– 41, PPAR beta– 3,PPAR gamma 2–6, PGC1alpha -12 CCAAT/enhancer binding protein C/EBP alpha– 24,C/EBP beta—18 C/EBP delta– 14,Glucose Transporter 4–9,Tumor Necrosis Factor Alpha-18, Adiponectin [ADIPOQ]– 8,PR domain containing 16–7,PREF1–11,Necdin– 7 Lipin1- 8,Sterol regulatory element binding transcription factor 1 SREBP1c- 6 |
Module 4a | CTNNB1 | Adipose Tissue | Inhibitor of Adipogenesis | Catenin [cadherin-associated protein], beta 1 CTNNB1–12 HNF1 homeobox A [TCF]– 9 |
Module 5 | Distinct SetsSignalling | -------- | -------- | --------- |