Table 3. Describes information of five modules obtained from the network.

The columns show pre-dominant hub, likely anatomical component and physiological process with the connectivity degree of major molecules.

Modules	Pre-dominant Molecule	Likely Anatomical Component	Physiological Process	Major Molecules with their degree of connectivity
Module 1	Leptin	Central Nervous System	Satiety, Appetite, Energy expenditure	Leptin [LEP]– 14, Dopamine– 9, Catecholamine– 8,Ghrelin—Growth Hormone Segretagogue Receptor[GH-GHSR]-5, Agouti-related Protein [AGRP]– 8, Pro-opiomelanocortin [POMC]– 6, NeuroPeptide Y [NPY]– 7,Tyrosine Hydroxylase—4, Adregenic Receptor Alpha 1B [ADRA1B]-3
Module 2	Insulin	Pancreas	Glucose metabolism	Insulin [INS]– 21,Forkhead box A2 [HNF3B]– 6,Pancreatic and Duodenal Homeobox 1 [PDX1]– 7,Forkhead box O1[FOXO1]– 6,Interleukin 6 [IL6]– 5 Leptin [LEP]– 5,Insulin receptor substrate 1 [IRS1]– 6, Insulin receptor substrate 2[IRS2]– 5,Insulin receptor– 5
Module 3	High Density lipoprotein	Liver & Gastro-Intestinal Tract	Fatty acid regulation and metabolism, Base-line glucose control.	Lipoprotein Lipase[LPL]– 6,High Density Lipoprotein– 12,Low Density Lipoprotein– 6,FXR alpha– 5,Cholesterol– 6
Module 4	PPAR gamma	Adipose Tissue	Store fat derived from the diet and liver metabolism or degrades stored fat to supply fatty acids and glycerol to the circulation.	Peroxisome proliferator-activated receptor PPAR alpha– 9,PPAR gamma– 41, PPAR beta– 3,PPAR gamma 2–6, PGC1alpha -12 CCAAT/enhancer binding protein C/EBP alpha– 24,C/EBP beta—18 C/EBP delta– 14,Glucose Transporter 4–9,Tumor Necrosis Factor Alpha-18, Adiponectin [ADIPOQ]– 8,PR domain containing 16–7,PREF1–11,Necdin– 7 Lipin1- 8,Sterol regulatory element binding transcription factor 1 SREBP1c- 6
Module 4a	CTNNB1	Adipose Tissue	Inhibitor of Adipogenesis	Catenin [cadherin-associated protein], beta 1 CTNNB1–12 HNF1 homeobox A [TCF]– 9
Module 5	Distinct SetsSignalling	--------	--------	---------