Table 3.
Radiation necrosis versus recurrent HGG: Summary of literature results.
| Study (n) | Group (n) | Mean rCBV | Mean PSR (%) | rCBV threshold (Sn%; Sp%) | PSR threshold (%) (Sn%; Sp%) | Comments | Level of evidenceb | |
|---|---|---|---|---|---|---|---|---|
| Di Constanzo 2008 (29) | GBM (21) | 1.73a | NA | Not provided | NA | Retrospective. Significant variation in treatment history and regimes. Some patients on steroids. Not all cases histopathologically confirmed. | 4 | |
| RN (8) | 0.86a | NA | ||||||
| Hu 2009 (40) | HGG (24) | 0.55 - 4.64 | NA | 0.71 (91.7; 100) | NA | Retrospective. Mean rCBV and P values not provided. Significant variation in radiotherapy dose. | 4 | |
| RN (16) | 0.21 -0.71 | NA | ||||||
| Barajas, Chang, Segal 2009 (57) | GBM (40) | 2.38a | 80.2a | 1.75 (78.92; 71.58) | 87.3 (78.26; 76.19) | Retrospective. Not all cases were histopathologically confirmed. | 4 | |
| RN (17) | 0.82a | 89.3a | ||||||
| Fink 2012 (40) | HGG (30) | 3.62a | NA | 2.08 (86.2; 90) | NA | Retrospective. Not all cases were histopathologically confirmed. | 4 | |
| RN (10) | 1.31a | NA | ||||||
a
P < 0.05.
bSee Appendix A.
GBM: glioblastoma; HGG: high-grade glioma; MET: metastasis; NA: not studied; PSR: percentage of signal intensity recovery; rCBV: relative cerebral blood volume; RN: radiation necrosis; Sn: sensitivity; Sp: specificity; vs.: versus