Table 4.
Radiation necrosis vs. recurrent metastasis: Summary of literature results.
| Study (n) | Group (n) | Mean rCBV | Mean PSR (%) | rCBV threshold (Sn%; Sp%) | PSR threshold (%) (Sn%; Sp%) | Comments | Level of evidenceb | |
|---|---|---|---|---|---|---|---|---|
| Hatzoglou 2013 (12) | GBM/MET (5) | Not provided | 1.8 (100; 71) | 74 (60; 100) | Retrospective. GBM and MET mixed. Very small study size. Mean rCBV, PSR and P values for each group not provided. | 4 | ||
| RN (7) | Not provided | |||||||
| Barajas, Chang, Sneed 2009 (34) | MET (23) | 2.38a | 60.64a | 1.54 (91.3; 72.73) | 76.3 (95.65; 100) | Retrospective. Not all cases histopathologically confirmed. | 4 | |
| RN (11) | 1.54a | 83.33a | ||||||
| Mitsuya 2010 (28) | MET (7) | 1.0a | NA | 2.1 (100; 95.2) | NA | Retrospective. Lesions not histopathologically confirmed. | 4 | |
| RN (21) | 3.5a | NA | ||||||
| Huang 2011 (27) | MET (18) | 2.49a | 81 | 2.0 (56; 100) | Not provided | Retrospective. PSR not statistically significant between groups. | 4 | |
| RN (9) | 1.03a | 80 | ||||||
a
p < 0.05.
bSee Appendix A.
GBM: glioblastoma; HGG: high-grade glioma; MET: metastasis; NA: not studied; PSR: percentage of signal intensity recovery; rCBV: relative cerebral blood volume; RN: radiation necrosis; Sn: sensitivity; Sp: specificity; vs.: versus