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. Author manuscript; available in PMC: 2016 Feb 17.
Published in final edited form as: ACS Nano. 2015 Jun 17;9(7):6900–6908. doi: 10.1021/acsnano.5b00545

Fig. 1. Generation and characterization of aligned collagen scaffold.

Fig. 1

(A) Schematic of fabricating aligned collagen scaffold in which collagen liquid crystal in the nematic phase (i) is sheared onto glass to create aligned liquid crystal collagen (ii) and then allowed to evaporate, forming an aligned nanofibrillar collagen film (iii). The aligned collagen film then self-assembles into a thread-like scaffold. (B) AFM shows aligned, crimped nanofibrillar scaffold structure. SEM shows the crimped micro-scale structure along the surface (C) and porous structure by cross-sectional view (D). Scale bars: 10 μm (C), 100 μm (D). Double arrows denote orientation of nanofibrils.