Figure 4. Functional features of gut microbiota in gout.

(A) The metabolism of purine degradation. The enzymes in red were enriched in the gout patient group and those in green were enriched in the healthy (control) group. (B) Comparison of COGs between the patient and the control groups. A: RNA processing and modification; J: Translation, ribosomal structure and biogenesis; D: Cell cycle control, cell division, chromosome partitioning; M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport; V: Defence mechanisms; H: Coenzyme transport and metabolism; P: Inorganic ion transport and metabolism; R: General function prediction only. The capital letters in red represent those functions enriched in the gout patient group, while the capital letters in blue represent those functions enriched in the control group. (C) Comparison of distribution of COGs of xanthine dehydrogenase and allantoicase between the patient and the control groups.