Table 1. Prostate cancer cell line used in bone metastasis research.
| Cell line | Origin | PSA | AR | Bone lesion | Model | References |
|---|---|---|---|---|---|---|
| DU145 | Central nerve system metastasis (Human) | Negative | Negative | Osteolytic | Intratibial injection, Intracardiac injection, Intravenous injection into human bone implanted animals | Conley-LaComb et al.,3 Stone et al.,4 Nemeth et al.,5 Yin et al.6 |
| PC-3 | Vertebral bone metastasis (Human) | Negative | Negative | Osteolytic | Intratibial injection, Intrafemoral injection, intracardiac injection, Intravenous injection into human bone implanted animals | Kaighn et al.,7 Nemeth et al.,5 Chu et al.,8 Wu et al.,9 Zhang et al.10 |
| LNCaP | Lymph node metastasis (Human) | Positive | Positive | Osteoblastic/Osteolytic | Intrafemoral injection, Intravenous injection into human bone implanted animals | Nemeth et al.,5 Horoszewicz et al.,11 Wu et al.9 |
| LNCaP C4-2 | LNCaP subline C4 xenograft line | Positive | Positive | Osteoblastic | Intratibial injection, Intrafemoral injection, intracardiac injection | Thalmann et al.,12 Wu et al.9 |
| LNCaP C4-2B | LNCaP subline C4-2 xenograft line | Positive | Positive | Osteoblastic | Intrafemoral injection | Thalmann et al.,12 Wu et al.9 |
| MDA PCa 2b | Bone metastasis (Human) | Positive | Positive | Osteoblastic | Intrafemoral injection | Navone et al.,13 Cheng et al.,14 Yang et al.15 |
| VCaP | Vertebral bone metastasis (Human) | Positive | Positive | Osteoblastic | Intratibial injection | Korenchuk et al.,16 Kirschenbaum et al.17 |
| 22Rv1 | CWR22R xenograft line | Positive | Positive | Osteoblastic/Osteolytic | Intratibial injection | Sramkoski et al.,18 Henry et al.19 |
| LAPC-9 | Femoral bone metastasis (Human) | Positive | Positive | Osteoblastic | Intratibial injection | Craft et al.,20 Lee et al.,21 Lee et al.22 |
| ARCaP | Ascites of a patient with advanced metastatic disease (Human) | Positive | Positive | Osteoblastic/Osteolytic | Intracardiac injection | Zhau et al.,23 Odero-Marah et al.,24 Xu et al.25 |
| LuCaP23.1 | Lymph node metastasis (Human) | Positive | Positive | Osteoblastic | Intratibial injection | Ellis et al.,26 Morrissey et al.,27 Brubaker et al.28 |
Abbreviations: AR, androgen receptor; PSA, prostate-specific antigen.