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. 2015 Aug 17;35(17):2166–2177. doi: 10.1038/onc.2015.282

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Copyright © 2016 Macmillan Publishers Limited

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FOXM1 is elevated and activated in malignant melanoma. (a) Ingenuity Pathway Analysis (IPA; Version build 242990) for upstream regulators in data sets obtained from Oncomine.^{43, 44} Shown are those genes predicted to be activated based on upstream regulator analysis (z-score) and that are themselves upregulated at least 1.5-fold with a P-value <0.05. (b) Expression of FOXM1 mRNA in two independent Oncomine data sets,^{44, 45} comparing primary melanoma vs metastases. P-values are indicated. (c) Analysis of copy number variation of FOXM1 in two independent Oncomine data sets⁴⁶ (and The Cancer Genome Atlas melanoma). CDKN2A is shown as a control and is known to show a reduction in copy number in many melanomas.¹⁵ (d) Co-expression analysis for genes correlating with FOXM1 in two independent Oncomine data sets,^{43, 47} showing the top candidates to co-express with FOXM1 in melanoma.