Table 1. Differential expression of miRNAs derived from small RNA sequencing in HepG2 cell after activation of p53.
| miRNA | Replicate 1 | Replicate 2 | Type | Host Gene | ||||
|---|---|---|---|---|---|---|---|---|
| log2(fold change) | p-value | Sig-lable | log2(fold change) | p-value | Sig-lable | |||
| hsa-miR-675-5p | -2.26 | 0.00E+00 | ** | -2.84 | 2.09E-12 | ** | Intron/Exon | H19 |
| hsa-miR-125a-3p | -1.16 | 7.18E-03 | ** | -1.08 | 1.67E-13 | ** | Intergenic | |
| hsa-miR-148a-3p | -1.46 | 6.74E-12 | ** | -1.21 | 0.00E+00 | ** | Intergenic | |
| hsa-miR-18a-5p | -1.37 | 1.01E-07 | ** | -1.47 | 6.01E-37 | ** | Intron | MIR17HG |
| hsa-miR-92a-1-5p | -1.51 | 2.20E-160 | ** | -1.55 | 1.00E-61 | ** | Intron | MIR17HG |
| hsa-miR-1277-5p | -1.8 | 1.22E-06 | ** | -2.54 | 6.31E-21 | ** | Intron | WDR44 |
| hsa-miR-20a-5p | -1.56 | 6.44E-65 | ** | -1.12 | 4.98E-104 | ** | Intron | MIR17HG |
| hsa-miR-210-3p | -1.06 | 5.45E-10 | ** | -1.49 | 5.12E-75 | ** | Intergenic | |
| hsa-miR-222-5p | -1.03 | 1.91E-02 | * | -1.53 | 3.62E-32 | ** | Intergenic | |
| hsa-miR-27a-5p | -1.14 | 2.53E-02 | * | -3.2 | 0.00E+00 | ** | Intergenic | |
| hsa-miR-27b-5p | -1.73 | 3.66E-34 | ** | -1.38 | 7.43E-202 | ** | Intron | C9orf3 |
| hsa-miR-29a-5p | -1.48 | 5.16E-03 | ** | -1.16 | 4.15E-03 | ** | Intergenic | |
| hsa-miR-19a-3p | -2.6 | 7.80E-05 | ** | -1.32 | 3.74E-321 | ** | Intron | MIR17HG |
| hsa-miR-33a-5p | -1.26 | 1.59E-88 | ** | -3.01 | 4.51E-16 | ** | Intron | SREBF2 |
| hsa-miR-3662 | -3.22 | 9.13E-03 | ** | -2.15 | 4.24E-09 | ** | Intron | HBS1L |
| hsa-miR-7-1-3p | -1.41 | 5.85E-04 | ** | -1.07 | 1.60E-02 | * | Intron/Exon | HNRNPK |
| hsa-miR-4741 | -1.66 | 1.72E-02 | * | -1.43 | 2.86E-27 | ** | Intron | RBBP8 |
| hsa-miR-590-3p | -2.04 | 1.74E-04 | ** | -1.3 | 1.32E-06 | ** | Intron | EIF4H |
| hsa-miR-196a-3p | -1.77 | 4.93E-02 | * | -3.29 | 5.77E-11 | ** | Intergenic | |
| hsa-miR-4521 | -2.53 | 5.56E-40 | ** | -10.43 | 1.77E-52 | ** | Intergenic | |
| hsa-miR-1275 | -3.06 | 1.63E-02 | * | -10.08 | 2.42E-41 | ** | Intergenic | |
| hsa-miR-146b-5p | 1.07 | 9.65E-20 | ** | 1.08 | 4.91E-120 | ** | Intergenic | |
| hsa-miR-449b-5p | 9.92 | 4.06E-26 | ** | 8.5 | 1.02E-15 | ** | Intron | CDC20B |
| hsa-miR-449c-5p | 5.65 | 6.24E-300 | ** | 4.72 | 1.57E-209 | ** | Intron | CDC20B |
| hsa-miR-371a-5p | 6.92 | 6.48E-04 | ** | 6.88 | 1.22E-05 | ** | Intergenic | |
| hsa-miR-184 | 7.19 | 6.39E-164 | ** | 3.32 | 1.63E-13 | ** | Intergenic | |
| hsa-miR-34c-5p | 2.68 | 2.96E-19 | ** | 9.62 | 4.23E-33 | ** | Intergenic | |
| hsa-miR-3661 | 1.55 | 1.14E-02 | * | 3.46 | 1.16E-111 | ** | Intergenic | |
| hsa-miR-375 | 7.84 | 9.06E-07 | ** | 4.25 | 0.00E+00 | ** | Intergenic | |
| hsa-miR-4485-3p | 2.91 | 4.24E-06 | ** | 3.17 | 1.62E-135 | ** | Intron | MTRNR2L8 |
| hsa-miR-1323 | 2.11 | 1.34E-03 | ** | 6.78 | 2.72E-05 | ** | Intergenic | |
| hsa-miR-449a | 5.35 | 6.38E-22 | ** | 9.03 | 2.52E-22 | ** | Intron | CDC20B |
| hsa-miR-9-5p | 11.05 | 2.98E-56 | ** | 2.5 | 8.76E-17 | ** | Intron | C1orf61 |
*: p<0.05
**: p<0.01.