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Mutant p53 protects ETS2 from degradation. ETS2 is a labile protein with a short half-life. An E3-ubiquitin ligase binds to ETS2 and promotes its ubiquitin-dependent degradation. In the presence of mtp53, ETS2 is not ubiquitinated and becomes stable, which increases its abundance allowing it to recruit mtp53 to ETS target genes.
