Table 6.
Expression of STS and SULTs in endometrial cancer.
| Gene | Level | Regulation | References |
|---|---|---|---|
| STS | mRNA | ≈ Cancer/adjacent tissue; EC type 1 | Smuc and Rizner, 2009 |
Cancer/adjacent tissue; EC type 1 (74%) and type 2 (26%) |
Lépine et al., 2010 | ||
| Protein | 86% EC | Utsunomiya et al., 2004 | |
| 82% Cancer weak to moderate/normal endometrium weak (glandular cells) | Human Protein Atlas | ||
| Activity (E1-S) |
EC/normal endometrium |
Adessi et al., 1984; Prost et al., 1984; Naitoh et al., 1989; Urabe et al., 1989 | |
EC/normal endometrium |
Tanaka et al., 2003 | ||
| DHEA-S |
EC/normal endometrium |
Abulafia et al., 2009 | |
| SULT1E1 | mRNA | ≈ Cancer/adjacent tissue; EC type 1 | Hevir et al., 2011 |
Borderline Cancer/adjacent tissue; EC type 1 (74%) and type 2 (26%) |
Lépine et al., 2010 | ||
| Protein | 22% EC | Utsunomiya et al., 2004 | |
EC/adjacent endometrium |
Xu et al., 2012 | ||
| Not detected in cancer | Human Protein Atlas | ||
| SULT2B1 | mRNA |
Cancer/adjacent tissue; EC type 1 |
Hevir et al., 2011 |
| Protein | Moderate staining in cancer | Human Protein Atlas |
EC, endometrial cancer.
Cancer/adjacent tissue; EC type 1 (74%) and type 2 (26%)
EC/normal endometrium